EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CHEMISTRY & BIOCHEMISTRY OF SULFA DRUGS: THE INHIBITOR OF DIHYDROPTEROATE SYNTHESIS IN-VIVO

Tirthoraj Dan, Aditya Narayan Singh and Dr. Dhrubo Jyoti Sen*

ABSTRACT

Sulfonamide is a frictional group that is the basis of several groups of drugs, which are called sulphonamides, salfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulphonamide group. Sulfonamide formulations are supplied as combination of products having two main components, a sulfonamide and the synthetic diaminopyrimidines, trimethoprim and ormethoprim. These combinations are made that it acts on specific targets in bacterial DNA synthesis. Sulfonamides inhibit the bacterial enzyme dihydropteroate synthesis in the folic acid pathway. Sulfonamide antibiotics are used as veterinary medicines to treat infections in livestock herds. Moreover, sulfonamides are widely used such as anticancer, anti-inflammatory and antiviral activity. Allergies to Sulfonamids are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin, hence medications containing sulfonamides are prescribed carefully. Highest tissue concentrations of sulfonamide plus metabolites are found in the liver and kidney of various food-producing species, but the rather high rate of sulfonamide related violations in pig liver has decreased considerably over the past decades.

Keywords: Diaminopyrimidines, Trimethoprim, Ormethoprim, Dihydropteroate, Anticancer, Antiinflammatory, Antiviral.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )