SEMI-SOLID DISPERSION OF CARVEDILOL SOLID LIPID NANOPARTICLES FOR TOPICAL DELIVERY
M. Ranga Priya* and N. Jeevitha
Nanoparticles have become one of the most active areas of research in the field of drug delivery due to their ability to deliver drugs to the right place at appropriate times and in the right dosage. Great progress has been made in the treatment of a variety of diseases by using drug delivery systems including solid lipid nanoparticles (SLN). The present study deals with the semi-solid dispersion of carvedilol solid lipid nanoparticles for topical delivery prepared by solvent injection method using stearic acid, PEG 6000, propylene glycol, chloroform, and distilled water. Four different formulations (F1 to F4) were prepared in different quantity of PEG 6000 and characterized by scanning electron microscopy, transmission electron microscopy, differential scanning calorimetry, particle size by zeta sizer, polydispersity index, encapsulation efficiency, and in vitro drug release study. Average size and polydispersity index of the best formulation, F3 was found to be 242 nm and 0.283 respectively. Encapsulation efficiency of F3 was found to be 87.9% with zero order release pattern.
Keywords: Solid lipid nanoparticles, carvedilol, PEG.
[Full Text Article]