EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ESTIMATION OF SERUM ?2 MICROGLOBULIN IN ORAL CANCER AND POTENTIALLY MALIGNANT LESIONS OF ORAL CAVITY BY CHEMILUMINESCENCE IMMUNE ASSAY

Dr. Daya K. Jangam*, Dr. Sana Fatema, Dr. Priyanka Kale, Dr. Ashwini Desai

ABSTRACT

Introduction: Oral cancer is highly prevalent in Indian population. It accounts for approximately 30-40% of all cancers in India, tumor markers have been introduced for screening purpose, diagnosis, prognosis. Aim: To find out the correlation of the serum level of β2 microglobulin in patients with oral cancer and potentially malignant lesions of oral cavity and to evaluate its potential as a biomarker in early detection and prognosis. Materialsand methods: It was a case control study. The study comprised of three group of 60 subjects.Group I consisted of 20 subjects with clinically and histopathologicallydiagnosed cases of Oral cancer. Group II consisted of 20 subjects withoral potentially malignant lesion (PML) cases and group III consisted of control group with 20 healthy subjects without any deleterious habits. “Serum β2 microglobulin” was estimated using chemical luminiscenceimmuno assay kit. Biochemical parameter was compared between study group and control group. Results: There was increase in level of serum β2 microglobulin from stage I: 2072.5±316.0(ng/mL) to stage IV (3624.5±1591.7ng/ml.) of oral cancer and average serum β2 microglobulin level differed significantly between stage I and stage IV in oral cancer group. (p<0.05). Also the average serum β2 microglobulindiffered significantly across Moderately Differentiated and Well Differentiated groups (P-value<0.05). Conclusion: Study revealed that serum β2 microglobulinwas seen increased in oral cancer and a positive correlation of serum β2 microglobulin with the disease progression was noted. Therefore Serum β2 microglobulin can be used as a prognosticmarker for oral cancer.

Keywords: biomarker, chemiluminiscenceimmunoassay, oral cancer, potential malignant lesions, serum ?2 microglobulin.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )