EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVELOPMENT AND CHARECTERIZATION OF GLIBENCLAMIDE LIPOSOMAL FORMULATION

Ranjeetha A. R.*, Vazir Ashfaq Ahmed, Swathi K., Rashmitha N. M., Priyanka Raj G. and Monisha M. N.

ABSTRACT

The aim of the present investigation was to design a liposomes containing glibenclamide. Liposomes were prepared by the thin film hydration method by using chloroform as a solvent. Liposomes containing glibenclamide formulations were prepared by different concentration of lecithin and cholesterol by thin film technique. these formulations were evaluated for entrapment efficiency , zeta potential ,surface morphology and in vitro drug release. Coating of liposomes resulted increases the zeta potential. highest entrapment efficiency was observed in F1and F3 92%and 94%. The percent drug release from F1-F4 and CF1 was observed as follows F1-88.57%, F2-73.31%, F3-76.29%,F4-90.97%, and F1 coated as a CF1-69.85%. release kinetics folows the higuchi plot and non –fickian diffusion mechanism.

Keywords: Glibenclamide, liposomes, thin film hydration method, invitro – diffusion.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )