EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CARVEDILOL BY SOLID DISPERSION TECHNIQUE

U. T. Jadhao*, S. D. Sable, G. N. Dhembre, R. D. Ingole, S. P. Rathod, S. M. Deshmukh, Bodhankar V. R.

ABSTRACT

Carvedilol is a nonselective β-adrenergic blocking agent with α1-blocking activity and it is indicated for the treatment of mild-to-severe chronic heart failure and hypertension. By preparing solid dispersion of Carvedilol with poloxamer 188 and PVP K90 solubility of Carvedilol was significantly improved. Solid dispersion can be prepared in different ratios such as 1:1, 1:2, and 1:4. This prepared solid dispersion evaluated for drug content, solubility study and dissolution study. The drug content of different batches such as A1 is 78.99 %, A2 is 91.19%, A4 is 93.03%, B1 is 93.60%, B2 is 94.71% and B4 is 99.34 % respectively The solid dispersion technique with PVP K90 as a carrier provides a promising way to not only enhance the solubility but also dissolution rate of carvedilol.Tablet prepared by using sodium starch glycolate in 4% concentration shows 100% drug release in 30 min as compared to the tablets which can be prepared without superdisintegrants. After stability study of immediate release tablet there was no significant changes can be observed in Hardness, disintegration and % release of drug. It indicates that the prepared tablet is stable throughout the study.

Keywords: Carvedilol, PVP K90, Poloxamer 188, Solid dispersions, Solubility, Dissolution rate, etc.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )