IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CARVEDILOL BY SOLID DISPERSION TECHNIQUE
U. T. Jadhao*, S. D. Sable, G. N. Dhembre, R. D. Ingole, S. P. Rathod, S. M. Deshmukh, Bodhankar V. R.
Carvedilol is a nonselective β-adrenergic blocking agent with α1-blocking activity and it is indicated for the treatment of mild-to-severe chronic heart failure and hypertension. By preparing solid dispersion of Carvedilol with poloxamer 188 and PVP K90 solubility of Carvedilol was significantly improved. Solid dispersion can be prepared in different ratios such as 1:1, 1:2, and 1:4. This prepared solid dispersion evaluated for drug content, solubility study and dissolution study. The drug content of different batches such as A1 is 78.99 %, A2 is 91.19%, A4 is 93.03%, B1 is 93.60%, B2 is 94.71% and B4 is 99.34 % respectively The solid dispersion technique with PVP K90 as a carrier provides a promising way to not only enhance the solubility but also dissolution rate of carvedilol.Tablet prepared by using sodium starch glycolate in 4% concentration shows 100% drug release in 30 min as compared to the tablets which can be prepared without superdisintegrants. After stability study of immediate release tablet there was no significant changes can be observed in Hardness, disintegration and % release of drug. It indicates that the prepared tablet is stable throughout the study.
Keywords: Carvedilol, PVP K90, Poloxamer 188, Solid dispersions, Solubility, Dissolution rate, etc.
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