EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

UNAVAILING CLINICAL POTENTIAL OF GATIFLOXACIN, A PROMISING FLUOROQUINOLONE REVIEW

Majalekar Priyanka* and Shirote Pramodkumar

ABSTRACT

Gatifloxacin is 8-methoxy fluoroquinolone introduced by Bristol-Myers Squibb in 1999. In May 2006, gatifloxacin was withdrawn by Bristol-Myers Squibb from the market because of it‟s severe dysglycemic events. As well as by notification of Union Health and Family Welfare Ministry of India on 18 March 2011 banned the manufacture, sale as well as distribution of gatifloxacin containing oral and injectable formulations from market. Certain in vitro experiments & post marketing surveillance devoted that dysglycemia viz. hypoglycemia, hyperglycemia is more common with gatifloxacin. In today‟s COVID 19 pandemic situation, gatifloxacin can act as antiviral through RNA messenger inhibitor or inhibition of viral helicases, topoisomerases II at low concentration. The fluoroquinolones like gatifloxacin, ciprofloxacin, ofloxacin, levofloxacin were found to be clinically effective in the treatment of the single-stranded RNA HCV and the non-enveloped, encapsulated DNA polyomavirus BK. So, gatifloxacin can be used to combact against corona virus. Therefore, observed potential severity of the reaction and increasing use of gatifloxacin, it is important to be aware with this phenomenon.

Keywords: Gatifloxacin, Antibacterial, Dysglycemia, Antiviral, COVID 19.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )