ESTIMATION OF DOMPERIDONE AND PANTOPRAZOLE SODIUM BY AREA UNDER CURVE METHOD
Jyotsna R. Chopade* and Sonali Khalate
Background: A simple, accurate, rapid and precise spectrophotometric method has been developed for
simultaneous estimation of Pantoprazole and Domperidone in pharmaceutical dosage form. Method: This method
was based on UV spectrophotometric determination of two drugs, using Area under Curve method. It involves
measurement of area under curve in the range of 268-278 nm (For Pantoprazole) and 276-290 nm (For
Domperidone) for the analysis in methanol. Result: The linearity was observed in the concentration range of 2-12
μg/ml for Lafutidine and 3-18 μg/ml for Domperidone. The method showed good reproducibility and recovery with
% RSD less than 2. Method was found to be rapid, specific, precise and accurate, can be successfully applied for
the routine analysis of Lafutidine and Domperidone in bulk, and combined dosage form without any interference
by the excipients. The method was validated according to ICH guidelines.
Keywords: Domperidone and Pantoprazole sodium, Ultraviolet spectrophotometry, Area Under Curve method.
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