IMMUNOHISTOCHEMICAL STUDY OF INTRATUMORAL LYMPHOCYTES IN BREAST CANCER

*Tillyashaikhov M. N., Shomansurova N. S. and Nishanov D. A.

ABSTRACT

The landscape of the subpopulation composition of intratumoral lymphocytes in women with breast cancer was studied. Infiltration of the tumor with T-lymphocytes, as well as a subpopulation of the most significant effector cells of antitumor immunity: mature T-lymphocytes, T-helpers / inductors are shown. The presented results indicate the possibility of a quantitative study of the subpopulation composition of intratumoral breast cancer lymphocytes. These data can be used to develop protocols for immunocorrection in prognostically unfavorable groups. Of course, further research should be carried out taking into account the immunophenotypic characteristics of the tumor, in particular, the receptor molecules that mediate interactions with the cells of the immune system. Understanding and identifying biological markers of tumor growth form the individual molecular phenotype of transformed cells, which characterizes the degree of tumor malignancy, the ability to metastasize, hormonal sensitivity, the effectiveness of chemotherapy, etc. Thus, breast cancer is a genetically heterogeneous disease with various molecular biological and clinical features. Identification of the molecular phenotype of breast carcinomas is an important prognostic factor of the disease and allows personalizing the treatment of patients.

Keywords: Breast tumors, immune chemistry, histology, lymphocytes, immunity, molecular biological markers of oncogenesis, early diagnosis of tumor growth, prognosis of metastasis, oncological risk.