( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Ajibade Opeyemi Ganiyat, Collins Ovenseri Airemwen*, Johnbull Aiwaguore Obarisiagbon, Catherine Dupe Soni-Osayande and Michael Uwumagbe Uhumwangho


The aim of this study was to formulate mucoadhesive tablets of metronidazole using HPMC and neem gum (NG). Neem gum was extracted from the stem bark of Azadirachta indica tree. Metronidazole granules were prepared by wet granulation technique with the extracted neem gum at varying concentrations of 25-50%w/w. The granules formulated were evaluated for micromeritic properties. The granules were then compressed to tablets at a compression pressure of 30 N/m2. The tablets were evaluated for hardness, friability, bioadhesive strength, in vitro dissolution studies and release kinetics. Drug-excipients compatibility studies were also carried out using Fourier Transform Infrared (FTIR) spectroscopy. All formulated granules were free flowing with angle of repose between 25.1 - 30.6⁰ and Carr’s index of ≤ 11.2%. The granules were compressible with hardness of 6.4 - 8.2 kpa and friability of ≤ 0.81%, while the bioadhesive force was between 0.62 -1.95 N. Increase in concentration of the binder resulted in a corresponding increase in tablet hardness and bioadhesive strength and decrease in percentage friability. All batches fitted into the Higuchi model release kinetics. FTIR studies showed that the excipients and the active pharmaceutical ingredient (API) were compatible. NG exhibited good mucoadhesive property and a synergistic mucoadhesive effect was observed with the addition of hydroxypropylmethylcellulose (HPMC).

Keywords: Neem gum, mucoadhesion, metronidazole, mucosa.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database