ELECTROPHYSIOLOGICAL AND IMAGING ANALYSIS IN OPTIC NEURITIS

Dr. Afroz Khan and Dr. Rofadun Nisa*

ABSTRACT

Background: To study the electrophysiological and MRI changes in patients with Optic Neuritis. Design: Prospective study. Material And Method: A prospective single institutional study was conducted on 52 eyes of 49 patients having Optic neuritis who underwent electrophysiological and imaging (contrast-enhanced MRI) analysis. Results: The study revealed that 26.92% (14) of patients had contrast enhancement in Contrast (Gd) enhanced MRI whereas 73.08% (38) had no contrast enhancement on MRI. Also, it was revealed that the Visual Evoked Potential was abnormal in 86.54% (45) patients with increased p100 latency, deformed waveform in 7.69%(4) patients, and normal study in 5.77% (03) patients. Conclusion: From our study, it was concluded that most of the Optic Neuritis patients have abnormal VEP and their contrast enhancement in Gd- enhanced MRI in fewer patients. The contrast enhancement in fewer patients may be because of the smaller sample size. To determine the systemic and functional activity of the optic nerves and to expose the type of presentation, a detailed diagnostic workup with clinical characteristics, ophthalmological observations, electrophysiological testing, and imaging techniques (MRI) is useful.

Keywords: Optic Neuritis, VEP, MRI.