EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

SKIN LIGHTENING CREAM EXPOSURE ON SERUM ANTIOXIDANTS STATUS AND SELECTED HEAVY METALS IN SPRAGUE DAWLEY RATS

Bolawa O. Eniola, Aroloye A. Olaoluwapo, Balogun H. Damilola, Sogbanmu O. Temitope and Ebuehi, O. A. Taiwo

ABSTRACT

Introduction: Skin lightening creams have been used mostly by women in developing countries for over a decade. The preference to having a fair skin is wide. These creams have been shown to contain hydroquinone. Objectives: This study is to investigate the effects of skin lightening creams on antioxidant enzymes, heavy metal levels and histology of the skin and liver in rats. Methodology: Skin lightening creams were purchased and applied to rats’ skins for six weeks. Heavy metal levels were assessed in the serum, together with protein levels and antioxidant enzyme activities. Histopathological tests were also carried out in rats skin, liver and ovaries. Results: Application of skin lightening creams to rat skin led to a deposition of high concentrations of mercury and arsenic (above the Maximum Permissible Levels by the WHO), high levels of serum protein and increase in the concentrations of antioxidant activities. Histological examination of the skin and liver showed lesions in group 7 of the rats. Conclusion: The usage of skin lightening creams over a long period of time could have adverse health effects.

Keywords: Heavy metals, Skin lightening creams, Antioxidants, Histology, Serum protein.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )