SYNTHESIS AND BIOLOGICAL ACTIVITIES OF ISATIN DERIVATIVES OF Cu (II), Co(II), Cd(II) AND Au(III) COMPLEXES ARE POTENTIAL ANTICANCER DRUGS
Subrahmanyam Naidu P.V.*, Ooha Sai Perumala and Prakash MMS Kinthada
Bio-inorganic chemistry is a thriving field of drug research for cancer treatment. Transitional metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target specific therapeutics1. The biological evaluation of novel Isatin Anthranilic acid schiff base(amphoteric) derivatives and its metal complexes in several tumor cell lines by assessing their effects on cellular metabolism, real-time cell proliferation and induction of apoptosis is reported in this study3,4. These derivatives demonstrate a diverse array of biological and pharmacological activities including anti-bacterial, anti-fungal, and anti-cancer properties. This broad spectrum of biochemical targets has been facilitated by the synthetic versatility of isatin, which has allowed the generation of a large number of structurally diverse derivatives from nitrogen and C2 / C3 carbonyl moieties. The C3 isatin anthranilic acid schiff base derivatives are a multitargeted receptor tyrosine kinase inhibitor. The main objective of the study was to synthesize a novel series of 3-substituted isatin anthranilic acid metal complexes by reacting suitable compounds and systematically evaluate the biological activities such as cytotoxic and anticancer properties of various substituted analogs of Cu(II), Co(II), Cd(II) and Au(III) complexes of isatin against various cancer cell lines have been performed. The purity was checked by TLC by using silica gel- Gas stationary phase. The structure of synthesized compounds were elucidated by using Perkin Elmer FT-IR in KBr disc and PMR was taken on a Bruker AMX-(400MHz) FT- NMR using DMSO- d6 as a solvent and TMS as an internal standard. Some isatin derivatives of Au(III)complexes are isoelectronic with platinum. These findings are a promising class of cytotoxic agents in the cancer treatment and mode of action studies in medicinal chemistry.
Keywords: Isatin anthranilic acid schiff base, organometallic, cytotoxic, anticancer.
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