EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF ISATIN DERIVATIVES OF Cu (II), Co(II), Cd(II) AND Au(III) COMPLEXES ARE POTENTIAL ANTICANCER DRUGS

Subrahmanyam Naidu P.V.*, Ooha Sai Perumala and Prakash MMS Kinthada

ABSTRACT

Bio-inorganic chemistry is a thriving field of drug research for cancer treatment. Transitional metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target specific therapeutics1. The biological evaluation of novel Isatin Anthranilic acid schiff base(amphoteric) derivatives and its metal complexes in several tumor cell lines by assessing their effects on cellular metabolism, real-time cell proliferation and induction of apoptosis is reported in this study3,4. These derivatives demonstrate a diverse array of biological and pharmacological activities including anti-bacterial, anti-fungal, and anti-cancer properties. This broad spectrum of biochemical targets has been facilitated by the synthetic versatility of isatin, which has allowed the generation of a large number of structurally diverse derivatives from nitrogen and C2 / C3 carbonyl moieties. The C3 isatin anthranilic acid schiff base derivatives are a multitargeted receptor tyrosine kinase inhibitor. The main objective of the study was to synthesize a novel series of 3-substituted isatin anthranilic acid metal complexes by reacting suitable compounds and systematically evaluate the biological activities such as cytotoxic and anticancer properties of various substituted analogs of Cu(II), Co(II), Cd(II) and Au(III) complexes of isatin against various cancer cell lines have been performed. The purity was checked by TLC by using silica gel- Gas stationary phase. The structure of synthesized compounds were elucidated by using Perkin Elmer FT-IR in KBr disc and PMR was taken on a Bruker AMX-(400MHz) FT- NMR using DMSO- d6 as a solvent and TMS as an internal standard. Some isatin derivatives of Au(III)complexes are isoelectronic with platinum. These findings are a promising class of cytotoxic agents in the cancer treatment and mode of action studies in medicinal chemistry.

Keywords: Isatin anthranilic acid schiff base, organometallic, cytotoxic, anticancer.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )