A RADIOLOGICAL, MICROBIOLOGICAL AND CLINICAL EVALUATION OF THE REGENERATIVE POTENTIAL OF XENOGRAFT ALONE AND IN COMBINATION WITH 1% ALENDRONATE AND 1% METFORMIN GELS FOR INFRABONY PERIODONTAL DEFECTS- A RANDOMIZED CONTROL TRIAL
Mannepalli Madhusudhan MDS and *Jammula Surya Prasanna MDS
Objectives: The main aim of this study was to assess the competency of Xenograft (XG) alone and in combination with 1% ALN and 1% MF in the regeneration of periodontal bone defects. Materials and Methods: In this randomized interventional study, a total of 36 infra bony defects were randomly assigned to three groups, each group comprised of 12 defects: Group I with 1% ALN gel + XG (test), Group II with 1% MF gel + XG (test) and Group III with XG alone(active control). This was a split-mouth study. Clinical criteria like pocket depth (PD), relative vertical clinical attachment level (RVCAL) were assessed. Radiographic parameter like linear bone growth (LBG) was measured with the help of a grid. The microbial count (MC) was estimated by plaque sample. All the parameters were calculated prior to the beginning of the study and at six months. Statistical analysis was performed using the Chi-square and paired t-test. Results: The mean reduction of PD, gain in RVCAL, LBG and MC were statistically significant within the groups (p <0.05) from baseline to six months. However, MC was insignificant in group III (p-0.294) within the group, but was significant on the intergroup comparison. Conclusions: Using XG alone as well as in combination with 1% ALN and 1% MF has given appreciable results.
Keywords: Alendronate, Grid, Metformin, Regeneration, Vertical bone defects, Xenograft,
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