CHEMICAL CONSTITUENTS OF THE LEAVES OF BAUHINIA RACEMOSA LAM. AND MYCELIA OF CORDYCEPS SINENSIS (BERK.) SACC.
Mohammed Ali*, Kshipra Misra, Shahnaz Sultana and Showkat Rassol Mir
Bauhinia racemosa Lam. (Caesalpiniaceae), distributed in India and other regions of south eastern Asia, is used to cure diarrhoea, dysentery, epilepsy, liver ailments, blood diseases, fever, headache, inflammation, malaria, skin diseases, tumors and ulcers. Cordyceps sinensis (Berk.) Sacc. (family Cordycipitaceae) is an entomopathogenic fungus found on Tibetan Plateau in south-western China and Himalayan regions of Bhutan and Nepal. It is used to treat bronchitis, cancer, high cholesterol, colds, coughs, depression, diabetes, erectile dysfunction, fatigue, jaundice, alcoholic hepatitis, male sexual problems, kidney and liver disorders, and tuberculosis. Phytochemical investigation of a methanolic extract of the leaves of B. racemosa led to isolate a dimethoxy-di-α-D-xyloside characterized as α-D-4-methoxyxylopyranosyl-(2→1′)-O-α-D-4′-methoxyxylopyranoside (1) and a quercetin derivative identified as 2′-hydroxyquercetin 3-O-α-D-xylopyranosyl-(2′′→1′′′)-O-α-D-xylopyranoside (2). Column chromatography of a methanolic extract of the mycelia of Cordyceps sinensis afforded n-octacosanoic acid (3), an aliphatic alcohol formulated as n-nonacosan-13β-ol (4), a di-β-D-glycoside elucidated as β-D-glucopyranosyl-(6→1′)-O-β-D-glucopyranoside (5) and an acyl tri-α-D-glucoside having a structure established as arachidyl α-O-D-glucopyranosyl-(6′→1′′)-α-O-D-glucopyranosyl-(6′′→1′′′)-α-O-D-glucopyranoside (6). The structures of these phytoconstituents have been established by spectral data analysis and chemical reactions.
Keywords: Bauhinia racemosa leaves, Cordyceps sinensis mycelia, chemical constituents, isolation, characterization.
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