DESIGN AND EVALUATION OF ESOMEPRAZOLE TRANSDERMAL PATCH FOR ENHANCED THERAPEUTIC ACTIVITY

M. Sakthivel, M. Pavithra*, S. P. Senthil and R. Senthamari

ABSTRACT

The main aim of the work was to formulate and evaluate the Esomeprazole magnesium transdermal patch for enhanced therapeutics activity using different concentration of polymers, permeation enhancer and plasticizers by solvent casting method. The polymer are HPMC, pectin and sodium alginate; permeation enhancer are Dimethyl Sulfoxide which playing role of releasing hydroxide agents to penetrate through the skin; plasticizer are glycerin were to get thin, transparent, smooth, stable and high permeable transdermal patches. The patches undergoes physicochemical evaluation, in vitro drug release, in that P2 formulation shows maximum drug release of 99.03±0.09% when compared with other formulation, release kinetics of P2 formulation which follows zero order kinetics and non-fickian diffusion case II. The transdermal patch of P2 formulation which may improves the patient compliance and avoid first pass metabolism.

Keywords: Transdermal Drug Delivery System, Esomeprazole magnesium, Solvent casting method, Physicochemical evaluation, in vitro drug release.