FORMULATION, DEVELOPMENT AND EVALUATION OF MICONAZOLE OLEOGEL USING COCONUT OIL AS PENETRATION ENHANCER

Dolat Singh*, Shankar Lal Soni, Dr. Vandana Sharma, Dr. Mukesh Sharma and Nikhita Parihar

ABSTRACT

The main purpose of this study was to develop a topical drug delivery (Oleogel) of Miconazole to reduce the dose of the drug, to improve patient compliance, to avoid the side effects and increase local onset absorption. Miconazole is a triazole derivative to treat antifungal and antiprotozoal infections. Methods: Topical oleogel formulations of Miconazole were prepared using Carbopol 940 as a gelling agent with different penetration enhancer with their different concentrations. Nine different formulations were prepared and evaluated with respect to their color, spreadability, viscosity parameter, determination of pH, formulation drug content, in vitro drug release studies, zeta potential studies, and stability studies. The Compatibility study was carried out by Fourier-transform infrared (FT-IR) spectral analysis. Results: FT-IR study revealed that there were no any significant interaction between the drug, excipients and polymers. All the prepared formulations of miconazole show acceptable physical properties. The drug content and percentage yield were higher for F5 formulation among all formulation F5 shows better drug release. Stability study of the best formulation F5 (Coconut oil) shows that there was no difference in drug content and in vitro drug release studies. Conclusion: From the above observation results that this F5 formulation (Coconut oil) may be more encouraging topical substitute for the healing of fungal infections in the skin.

Keywords: Miconazole, Carbopol 940, oleogel, Zeta potential, Stability study.