EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FAST DISSOLVING HPMC E5 BASED ORAL FILM FOR RAPID ABSORPTION OF METOPROLOL TARTRATE

Gurdale Manmat S.*, Lade Milind S., Payghan Santosh A., Disouza J. I.

ABSTRACT

Fast dissolving oral drug delivery system are solid dosage form which disintegrate or dissolve within second when placed in the mouth without need of water or chewing, first developed fast dissolving dosage form consisted in tablet form and the rapid disintegrating properties were obtained through a special procedure or formulation modification, recently fast dissolving film are gaining interest as an alternative to fast dissolving tablet to eliminate fear of chocking. In present investigation, an attempt has been made to develop oral fast dissolving film of Metoprolol Tartrate (25mg), the film were prepared by solvent casting method in which solution was casted on glass surface by using film forming machine, the characterization of film was done by evaluating various film forming polymer and plasticizer, concentration of polymer and plasticizer were optimized by evaluating various physical and chemical properties of film , Metoprolol Tartrate ODF contain HPMC E5 as a polymer, Sucralose as a sweetener and glycerol as a plasticizer proves to be potential, various concentration of HPMC E5 and glycerol used and ODF formulation were made and various mechanical properties were analyzed. Formulation consisting HPMC E5 and glycerol were proving to be better ODF formulation , mechanical property of film like disintegration time, folding endurance were compared with marketed products like ONDEM OF , stability study done by comparing dissolution profile of fresh and stability sample.

Keywords: Metoprolol Tartrate, solvent casting method, film forming machine.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )