FORMULATION OF METOPROLOL TARTARATE CONTAINING LYOPHILIZED ORAL DISINTEGRATING TABLET

Mr. Shashank Gupta*, Pooja Shree Verma, Jagrati Chaurasia, Sanjay Jain

ABSTRACT

Orally Disintegration Tablet (ODTs) are solid dosage forms containing active pharmaceutical ingredient (API) which disintegrate rapidly, usually less than 60 seconds without the need of water when placed on the tongue. Metoprolol, which is practically water insoluble, shows low bioavailability. weighed 100mg metaprolol was dissolved in 100ml of methanol solution to get a solution containing 100mcg/ml. Dilution: Aliquots of (0.1-1.0ml) standard solution were pipette out into 10ml volumetric flasks. The volume was made upto the mark with methanol solution to produce the concentration ranging from 1-10 mg/ml. The absorbance of each prepared solution was measured at 222nm in Shimadzu UV-1800 spectrophotometer against an appropriate blank (Methanol solution). Lyophilization is one of the technique that can solve this problem in ODTs formulation. The resulting tablets were evaluated using parameters such as: hardness, friability, disintegration time in vitro, modified disintegration time, disintegration time in the oral cavity, wetting time, water absorption ratio, drug content determination, weight uniformity, and dissolution.

Keywords: ODTs (Oral disintegrating tablet), Lyophilized, Formulation, Metoprolol Tartarate, Disinteration, Gelatin.