COMPARATIVE STUDY OF WOUND HEALING ACTIVITY OF KHADIRA (ACACIA CATECHU WILLD) AND ARJUNA (TERMINALIA ARJUNA ROXB.) IN STREPTOZOTOCIN INDUCED DIABETIC WOUND IN SPRAGUE DAWLEY SPECIES ALBINO RATS.”

Dr. Surekha B. Khandekr* and Dr. T. A. Pansare

ABSTRACT

In Ayurveda Khadira and Arjuna are mentioned in Kashayaskandha (Group of astringents). Both possess Sheet Veerya, Katu vipaka and Ruksha guna, Pramehagna (anti- diabetic), Shothhar (antiinflammatory) properties. The present study was performed to compare diabetic wound healing activity of Khadira (Acacia catechu willd.) and Arjuna (Terminalia Arjuna Roxb.) in streptozotocin induced albino rats. All rats were injected with STZ intraperitoneally to induce diabetes. After a period of 1 month these diabetic animals were distributed in the different groups (n=6) such as DC (Disease control), STD (Standard drug), Test 1 drug (Khadira), Test 2 drug (Arjuna). Circular excision was made on a dorsum of every animal. Test drugs were applied to respective groups and wound area was measured on days 0, 3rd, 6th, 9th, 12th and 15th for all groups. Aqueous extract of Khadira and Arjuna both responded both of them have showed diabetic wound healing effect. The wound healing activity is more effective in Arjuna extract as compared to Khadira extract due to presence of tannin in high intense in Arjuna than Khadira.

Keywords: Khadira, Arjuna, Tannin, diabetic wound.