EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AN APPROACH TO ENHANCE THE SOLUBILITY OF RILPIVIRINE HYDROCHLORIDE USING SOLID DISPERSION TECHNIQUE

Kanchan Chauhan* and Saloni Shaikh

ABSTRACT

The aim of the current research was to enhance the solubility and dissolution characteristics of poorly water soluble drug rilpivirine by solid dispersion technique. The study includes solubility enhancement of rilpivirine by using several water soluble carriers such as PEG 6000, PEG 4000, polyvinyl alcohol in different ratios (1:2, 1:3, 1:4) and with different techniques such as solvent evaporation technique, Fusion method and microwave irradiation method. The solid dispersions were evaluated for various in vitro parameters such as dissolution study and Fourier transform infrared spectroscopy (FT-IR). The FTIR spectral analysis showed that there was no drug interaction with formulations additives of the tablet as there is no variation and shift in bands observed which justified that there is no interaction between drug and polymer. Solubility and dissolution rate of rilpivirine was found to be significantly higher in microwave-assisted solid dispersions. Solid dispersion of rilpivirine: PEG 6000 (1:3) exhibits fastest dissolution among all solid dispersions and thus it was selected for formulation. The solid dispersion of rilpivirine: PEG 6000 (1:3) was taken and formulated into tablets using direct compression method. The results indicated that formulated tablets of solid dispersions by microwave method gives better dissolution profiles. Microwave technology offers a simple, efficient, solvent-free promising alternative method to prepare solid dispersion with significant enhancement of solubility and dissolution rate.

Keywords: Rilpivirine, PEG 6000, solid dispersion, dissolution.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )