EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EVALUATION OF ANALGESIC EFFICACY AND SAFETY OF EPIDURAL MAGNESIUM SULPHATE, DEXMEDETOMIDINE AND KETAMINE AS ADJUVANTS TO BUPIVACAINE FOR INTRA OPERATIVE ANALGESIA IN EXPLORATORY LAPAROTOMY

Dr. Aatif Shah*, Dr. Kharat Mohd Butt

ABSTRACT

Background- Postoperative pain relief has always been a cause of concern for patients undergoing exploratory laparotomy. Epidual infusions of local anaesthetics are from times being used for the same. Various additives added to it may supplement the analgesic potency of local anesthetics. Studies to find the ideal additive have always been on the go. Objectives- This study aimed at evaluating intraoperative analgesia after lumbar epidural ketamine, magnesium sulphate or dexmedetomidine associated to 0.25% bupivacaine for exploratory laparotomy. Method- A randomized study was done. The patients undergoing elective exploratory laprotomy were divided into three groups (Group A, Group B, and Group C). Group A –patients who were to receive magnesium sulphate (n=20) Group B- patients who were to receive dexmedetomidine (n=20) Group C-- patients who were to receive ketamine(n=20) Isoflurane concentration and intraoperative analgesia(using clinical signs) was recorded. Results- Our study has observed decreased systemic systolic pressure in 60% of Ketamine, 25% of Clonidine and 30% of Dexmedetomidine group patients; heart rate was decreased in 15% of Ketamine and 10% of Dexmedetomidine group patients. Conclusion- The above results help us to conclude that epidural ketamine, dexmedetomidine and magnesium sulphate decrease the requirement of fentanyl and isoflurane inspired concentration in the intraoperative period of exploratory laprotomies.

Keywords: exploratory laparotomy ;epidural; intraoperative analgesia; isoflurane; safety.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia