EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AMLODIPINE INDUCED PETECHIAL RASH, COLD AND COUGH IN BREASTFEEDING YOUNG LADY-A CASE REPORT

Eva Lorel Kouassi* and Sheethal Kuriakose

ABSTRACT

Introduction: Amlodipine is a calcium channel blocker that is widely used in mild to moderate hypertension, chronic stable angina and vasospastic angina. Although many studies have reported its association with remarkable complications such as peripheral edema, flushing and headache, hypersensitivity reactions, cold and cough remain rare adverse reactions of this drug. Case report: This study presents a case of a 29 year old female lady with 38 weeks period of gestation. She was diagnosed with gestational hypertension 6 months ago for which antihypertensive (tablet nifedipine and labetalol) were prescribed. She was stabilized on 5 mg amlodipine once daily after which she developed cold, brownish black petechial rash over her neck and hands. History, clinical examinations and lab investigations revealed no abnormalities. The patient denied any previous use of medications other than the ones prescribed; consequently the diagnosis made was a diagnosis by exclusion. WHO ADR causality assessment was performed which placed this reaction as a probable adverse reaction to amlodipine. Hence the dose of amlodipine was decreased to 2.5 mg and lastly stopped. The rash resolved gradually over a period of three weeks. Discussion: The petechial rash experienced by the patient can mainly be explained by the increased hydrostatic pressure. The best management provided was withdrawal of the responsible drug. Conclusion: Amlodipine-induced cough; cold and petechial rash is a rare and cosmetically disagreeable adverse reaction which requires profound study for better understanding and management. This case highlights the necessity of rational drug use in vulnerable population like breastfeeding ladies.

Keywords: amlodipine, petechial rashes, cold.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )