COLLAGEN BASED DRUG DELIVERY SYSTEM

Ruchi Baherji, B. V. P. Deepthi*, Jafor Ali., B. Vinitha, P. Harika and Dr. JVC. Sharma

ABSTRACT

Collagen, a biopolymer finds its application in the preparation of pharmaceutical products that are used in wound management, ophthalmic, orthopaedic and oral surgeries. This wide applicability is due its special properties such as biodegradability, biocompatibility, easy availability and high versatility. Collagen is isolated from various sources such as bovine skin, fish skin, chicken skin, skin waste of marine organisms, solid wastes of leather industry, short tendons of slaughtered cattle and bone. The functional groups such as amino and carboxylic acid present in collagen helps in its modification that suits for various end uses which include wound healing, ophthalmic defects, drug delivery and tissue engineering applications. These beneficial properties impart uniqueness to collagen molecule among the available bio molecules. Due to its biodegradability, biocompatibility, weak antigenicity it is very useful carrier for the delivery of various kinds of drugs and agents like growth factors, collagen possess some very unique properties as compare to other drug carriers that’s why a numerous number of researches are in pipeline on this biomaterial. However, fundamental awareness regarding collagen biochemistry and the manufacturing knowledge in combination with understanding of the physico-chemical properties is essential for fruitful application of collagen for drug delivery systems. The purpose of this review article is to summarize information available on collagen dosage forms for drug delivery as well as to communicate an outline regarding current preparation of collagen available in market includes - collagen sponges for burns/wounds, mini-pellets and tablets, gel preparations in combination with liposomes for sustained delivery of drug.

Keywords: Biopolymer; Collagen; Drug delivery system; Biomaterial; Opthalmology.