EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

MICROALBUMINURIA AS A DIAGNOSTIC MARKER OF TUBULOINTERSTITIAL KIDNEY DAMAGE IN CHILDREN WITH SECONDARY OXALATE NEPHROPATHY

Sharipov Alisher Mirkhamidovich, Artikova Magina Akmalovna* and Mamatqulov Baxrom Bosimovich

ABSTRACT

In recent decades, the problem of nephrolithiasis has become more and more urgent among children and adults. It has been established that nephrolithiasis in almost 75 - 80% of cases consists of calcium salts, namely calcium oxalate (CaOx), which enters the body through food, but the bulk is formed endogenously. It has been determined that hyperoxaluria is common in diabetic and obese patients, contributing to an increased risk of stone formation. Moreover, untimely detected hyperoxaluria in childhood can lead to transformation into nephrolithiasis in adults. The main reason for close attention to hyperoxaluria is associated with complications in the form of nephrolithiasis, persistent urinary tract infection, interstitial nephritis and other manifestations, even in the first years of a child's life. In this regard, it is necessary to search for early diagnostic markers, including damage to the tubulointerstitial canal in children with hyperoxaluria. In recent years, there has been a marked increase in interest in microalbuminuria (MAU) as a marker of kidney damage. Considering the above, in our study we studied the age and gender characteristics, the effect of metabolic disorders on the development of secondary oxalate nephropathy (SON), the characteristics of urinary syndrome for this pathology, as well as the determination of MAU in children with SON. The results we obtained showed that in most cases we established the enteral type of SON. At the same time, a reliably significant relationship was determined between the degree of oxaluria and microalbuminuria in urine in children with enteral and idiopathic types of SON. Microalbuminuria was more pronounced in children with kidney microliths.

Keywords: microalbuminuria, diagnostic marker, children, secondary oxalate nephropathy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )