MICROALBUMINURIA AS A DIAGNOSTIC MARKER OF TUBULOINTERSTITIAL KIDNEY DAMAGE IN CHILDREN WITH SECONDARY OXALATE NEPHROPATHY

Sharipov Alisher Mirkhamidovich, Artikova Magina Akmalovna* and Mamatqulov Baxrom Bosimovich

ABSTRACT

In recent decades, the problem of nephrolithiasis has become more and more urgent among children and adults. It has been established that nephrolithiasis in almost 75 - 80% of cases consists of calcium salts, namely calcium oxalate (CaOx), which enters the body through food, but the bulk is formed endogenously. It has been determined that hyperoxaluria is common in diabetic and obese patients, contributing to an increased risk of stone formation. Moreover, untimely detected hyperoxaluria in childhood can lead to transformation into nephrolithiasis in adults. The main reason for close attention to hyperoxaluria is associated with complications in the form of nephrolithiasis, persistent urinary tract infection, interstitial nephritis and other manifestations, even in the first years of a child's life. In this regard, it is necessary to search for early diagnostic markers, including damage to the tubulointerstitial canal in children with hyperoxaluria. In recent years, there has been a marked increase in interest in microalbuminuria (MAU) as a marker of kidney damage. Considering the above, in our study we studied the age and gender characteristics, the effect of metabolic disorders on the development of secondary oxalate nephropathy (SON), the characteristics of urinary syndrome for this pathology, as well as the determination of MAU in children with SON. The results we obtained showed that in most cases we established the enteral type of SON. At the same time, a reliably significant relationship was determined between the degree of oxaluria and microalbuminuria in urine in children with enteral and idiopathic types of SON. Microalbuminuria was more pronounced in children with kidney microliths.

Keywords: microalbuminuria, diagnostic marker, children, secondary oxalate nephropathy.