LIVER METASTASIS OF MELANOMA OF UNKNOWN PRIMARY TUMOR: A CASE REPORT
Layla Ben Youness*, Mohamed Saadoune, Mouna Darfaoui, Issam Lalya, Abdelhamid Elomrani and
Mouna Khouchani
ABSTRACT
The natural history of metastatic melanoma in liver in the absence of a known primary site (MUP) has been defined poorly, thus, treatment guidelines for patients with MUP are not clear-cut. A 70-year-old male patient, with no prior history, The symptomatology began 1 year ago by the gradual installation of isolated asthenia gravis without anorexia or weight loss and without other signs of digestive, pulmonary or cutaneous appeal. The pelvic abdominal chest CT found a liver with multiple nodular lesions, after biopsy of this lesions the anatomo-pathological study a morphological and immunohistochemical aspect of melanoma the rest of the investigation did not object to any abnormalities, notably digestive endoscopy. the diagnosis is retained of MUP. A palliative chemotherapy is started with dacarbazine which led to a stability of lesions after one year of follow-up. he relatively favorable long-term survival of patients with MUP in the current study suggested that patients with MUP have a natural history that is similar to (if not better than) the survival of many patients with Stage III disease.
Keywords: Melanoma, liver metastasis, unknown primary tumor.
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