EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DIABETIC CARDIOMYOPATHY: A REVIEW

Supriya Roy, Tarique Mahmood* and Arshiya Shamim

ABSTRACT

Diabetes is recognized as a prevalent risk factor for cardiovascular morbidity and mortality. The core metabolic defects that mark diabetes, including impaired glucose tolerance, insulin resistance and proinflammatory state leading to endothelial dysfunction forms the pathogenesis of diabetic cardiomyopathy. Hyperglycemia triggers series of maladaptive stimuli that result in myocardial fibrosis and collagen deposition. Hyperglycemia induced mitochondrial reactive oxygen species (ROS) is also a significant contributor. Moreover, increases in sympathetic tone with diabetes are associated with changes in cardiac and vascular functions. ANS is responsible for modulating the activity of the sinus node (heart rate), ventricular (end systolic and diastolic volume) and blood vessels (systemic vascular resistance) and the dysfunction of the ANS may contribute to the development of arterial stiffness, left ventricular hypertrophy and ventricular diastolic dysfunction and cardiac autonomic neuropathy; such changes forms the symptoms for cardiomyopathy. Echocardiography is the preferred diagnostic approach for diabetic cardiomyopathy. Magnetic resonance imaging and spectroscopy along with contrast agents are now leading approaches in the diagnosis of myocardial fibrosis, cardiac and metabolic changes. Also, serum biomarkers offer clear picture of diabetes induced structural and functional changes in cardiac even at very early stages of the disease. Currently, there is no specific treatment for diabetic cardiomyopathy. The pillars in the treatment of diabetic cardiomyopathy include lifestyle changes, intense glycemic control through diet, oral hypoglycemics and insulin, modification of risk factors for cardiovascular disease, and management of heart failure symptoms. Although glycemic control is the main therapeutic approach, newer treatment targets are currently being explored.

Keywords: Diabetic cardiomyopathy (DCM), diabetes, cardiovascular disease, myocardial fibrosis, left ventricular hypertrophy.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )