“BIOAVAILABILITY ENHANCEMENT OF DRUGS FOR THERAPEUTIC APPROACHES AND FUTURE TREND”

Makwana Rajeshree* and Dr. Kinjal H. Shah

ABSTRACT

The solubility issues complicating the delivery of these new drugs also affect the delivery of many existing drugs. The various traditional and novel techniques that that can be used for solubility enhancement of BCS Class drugs. Bioavailability refers to the rate and extent of the drug absorbed in the systemic circulation after administration. Oral delivery, the most convenient mode of drug administration has certain limitation. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Thus, a major amount of the drug is wasted and the unabsorbed drug leads to undesired side effects in the gastrointestinal tract. Various approaches are used for bioavailability enhancement of the orally administered drugs. The present review focuses on the importance of bioavailability, for therapeutic approaches and future trend.

Keywords: Therapeutic effectiveness, bioavailability enhancement, solubility.