EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHARMACOLOGICAL SCREENING FOR ANTI-INFLAMMATORY, ANALGESIC, AND CNS DEPRESSANT ACTIVITIES OF THE METHANOL AND ETHYL ACETATE FRACTIONS OF STEREOSPERMUM PERSONATUM (HASSK.) CHATTERJEE LEAVES IN MICE

Luthfun Nesa*, Md. Akherul Islam, Mohammad Amzad Hossain, Md. Monirul Islam, Asma Kabir and Mohammad Sirajum Munir

ABSTRACT

Aims: The study was carried out to assess anti-inflammatory, analgesic and CNS depressant activities of methanol & ethyl acetate fractions of Stereospermum personatum leaves. The methanol and ethyl acetate fractions (200mg/kg and 400mg/kg dose) were ingested to determine the acetic acid-induced writhing, formalin induced licking and biting, carrageenan induced hind paw edema and CNS depressant activity by open field and hole cross test. The both fractions (400mg/kg) exhibited moderate analgesic activity (57.55% and 56.1%) against acetic acid induced pain compared to standard (83.02%). Though the both fractions (400mg/kg) showed same analgesic effect (54.57% and 56.43%) at early phase but only ethyl acetate fractions (400mg/kg) is effective (58.21%) at late phase of formalin induced compared to standard (59.70%). The both fractions (200mg/kg and 400mg/kg) exhibited significant anti-inflammatory activity at 1st h to 4th hours. The two fractions (200mg/kg and 400mg/kg) showed significant (*p<0.05) depressant activity at 30min to 120min in the hole cross and open field test. This study observed that the effect of methanol and ethyl acetate fractions of Stereospermum personatum leaves (400mg/kg) were almost similar but only 400mg/kg dose has shown moderate analgesic, significant CNS depressant action and mild anti-inflammatory activity

Keywords: Stereospermum personatum, Analgesic, acetic acid, Formalin, anti-inflammatory, CNS Depressant


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )