EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

INCIDENCE AND RISK FACTORS PREDISPOSING TO RETINOPATHY OF PREMATURITY AND TREATMENT OUTCOME: A RETROSPECTIVE COHORT STUDY

Mittal Deepak, Sidana Poonam, Jain Mayank*, Gupta Aparna and Mehta A.P.

ABSTRACT

Purpose: Retinopathy of prematurity is a disorder of the developing retina. The survival rate of preterm infants increased due to advance neonatal care, with a consequent increase in retinopathy of prematurity cases. The aim was to assess the incidence of ROP and its risk factors and outcome for those who needed treatment. Methods: A retrospective cohort study of the preterm infants born in a tertiary intensive care unit was conducted from January 2017 to October 2020. A total of two hundred three newborns included for this study based on the following criteria, Gestational age (GA) at the time of birth of ≤35 weeks, birth Weight of ≤2000 gm, and babies with GA>35 weeks and BW >2000 if the treating Paediatrician recommended ROP screening due to stormy course in NICU. Data were review to determine the incidence and risk factors of ROP. Neonates were followed up until disease resolution or until treatment criteria were achieved. Results: A total of two hundred three babies enrolled in this study. There were 126 (62.1%) males and 77 (37.9%) females. ROP seen in 41 babies and giving an incidence of 20.2%. About half of cases had stage 1 ROP (51.2%) followed by stage 2 (24.4%), APROP (22%) and stage 3 (2.4%). No case of stage 4 and stage 5 ROP were detected. 7 out of 41 ROP cases were type-1 disease with the incidence of 3.4% and received treatment. A significant association noted between ROP and PDA, sepsis, PVL, BPD, RDS, Postnatal steroids, oxygen therapy blood transfusion, TPN (P <0.05). No significant association was found for PIH, Preeclampsia, GDM, receiving antenatal steroids, IVH, multiple gestations, SGA, NEC, invasive and non-invasive respiratory support need. Conclusion: This study found the incidence of any stage of ROP was 20.2%, and the incidence of type-1 disease was 3.4%. A significant association noted between ROP and PDA, sepsis, PVL, BPD, RDS, Postnatal steroids, oxygen therapy blood transfusion, TPN.

Keywords: Retinopathy of prematurity, Risk factors, Type 1 ROP disease, Incidence.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia