EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

PREPARATION, CHARACTERIZATION AND IN-VITRO EVALUATION OF PIROXICAM MICROSPHERES

Esmat E.Zein*, Sanaa El-Gizawy and Sania El-kayad

ABSTRACT

Non- steroidal anti-inflammatory drugs (NSAIDs) are commonly used particularly in elderly patients for both rheumatic as well as non-rheumatic conditions. Elderly patients are more prone to the adverse effects of these drugs. Adverse effects are seen in almost every organ system, but GI tract is most frequently affected as they cause GI irritation, bleeding and also peptic as well as duodenal ulceration. Piroxicam is one of these drugs which are commonly used for treatment of ankylosing spondylitis, osteoarthritis and rheumatoid arthritis which need long term treatment. In order to reduce the GI side effects of piroxicam, microspheres of the drug were prepared with different polymers of time dependant eudragit polymers. Different techniques of microencapsulation were experienced to prepare controlled release formulations of .piroxicam. Solvent evaporation technique was the technique of choice for this purpose. The obtained microspheres were evaluated using scanning electron microscopy (SEM) as well as IR spectroscopy. The obtained results showed the presence of intermolecular hydrogen bonding between the drug and polymer. SEM indicated that microspheres have rough and porous surface due to solvent evaporation during preparation. Drug percent yield was measured and ranged from74.24% to 92.03% .Dissolution studies which were performed at pH 1.2, 6.8 and 7.4 (representing stomach and intestinal conditions respectively) showed that the drug release was continuous and faster at pH 7.4 and the cumulative drug release reached 89% within 8 hrs.

Keywords: Piroxicam, ankylosing, dependant eudragit.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia