EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN-SILICO STUDY: PROTEIN STRUCTURE PREDICTION, COMPARISON AND COMPARATIVE STRUCTURAL ANALYSIS BY ALIGNMENT OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 NUCLEOCAPSID PROTEIN (SARS-COV-19 N PROTEIN) AND DIFFERENT ORGANISM’S HOST WITH ACE2 PROTEIN

Krushna K. Dishware*, Dr. Faiyaz K. Shaikh and Dr. Sanjay N. Harke

ABSTRACT

Human beings are presently experiencing a serious global public health issue that is Coronavirus disease 19 (COVID-19). The World Health Organization (WHO) on March 11, 2020, has declared the novel Coronavirus disease 19 (COVID-19) outbreak a global pandemic. Coronavirus disease 19 (COVID-19) has a single - stranded RNA genome. There are seven strains of human Coronavirus (CoVs) ,out of those three strains are highly pathogenic (SARS-CoV, MERS-CoV, 2019-nCoV), which causes an endemic of severe Coronavirus (CoV) disease. The most important four structural proteins of COVID-19 are S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The nucleocapsid protein is one of the core components of the SARS-CoV-2. Nucleocapsid protein alone is able to form the capsid. In this present work, we have predicted tertiary structure of human, Bats (Pteropus vampyrus), Mus musculus with ACE2 protein with the help of Swiss model (automated protein structure homology-modelling server). Protein structure alignment and comparison of different organism's host with ACE2 protein and SARS-CoV-2 Nucleocapsid protein using PyMol (3-Dimensional structure visualization Tool). We also performed Superimposition of proteins, comparative structural analysis. Calculate their RMSD (Root Mean Square Deviation) and RMS score.

Keywords: COVID-19, SARS-CoV-2 Nucleocapsid protein, Structure prediction, Structure alignment and comparison, comparative structural analysis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )