SYNTHESIS OF NEW AZETIDINONE DERIVATIVES CONTAINING QUINAZOLINONE MOIETY AND THEIR UTILISATION AS ANTIFUNGAL ACTIVITY

Sanjeev Kumar Bhatt, Indu Singh*, Gaurav Kumar and Deepak Kumar Gautam

ABSTRACT

2-methyl-4H-benzo[d][1,3]oxazin-4-one derivatives (1) is made by the reaction of amino acid and (CH3CO )2O. It preformed the heating Reaction. Compound 2 was synthesized from 2-amino phenol and then reacted with acetic acid and bromine gave compound 3. Compound 3 was converted in compound 4 by the reaction of hydrazine. Compound 4 on condensation with aromatic aldehydes gave Schiff base and then reacted with chloroacetyl chloride to give azetidinones. Newly synthesized compounds were confirmed by TLC using, and newly synthesis molecules’s structures were confirmed by the elemental analysis (carbon, hydrogen and nitrogen), IR and 1HNMR spectral data and also these synthesized compounds work evaluated for their biological antifungal activity against candida albicans, candida albicans ATCC, candida krusei. Among the synthesized compounds, compounds containing chloro substituent have shown significance antifungal activity.

Keywords: benzoxazinone, quinazolinone, azetidinone, antifungal activity.