A BRIEF REVIEW OF SELF ASSEMBLED CERAMIC NANOPARTICLES AND THEIR APPLICATIONS

*Kakaraparthi N. K. L. R. Spandana M. Pharm, Mulakallapalli Anusha M. Pharm, A. Divya Bharathi M. Pharm, Y. Prasanth M. Pharm (Ph.D).

ABSTRACT

Aquasomes are nanoparticulate carrier systems. These are three layered self assembled structures composed of nanocrystalline core coated with oligomeric polyhydroxy carbohydrate film, on which biochemically active molecules of drug are adsorbed with or with out modification. Aquasomes are spherical shaped particles with a size range of 60-300nm. Generally it is given through iv route. But due to the development of Research and development it can be delivered through other routes. Aquasomes can be compressed as tablets by using multi functional excipients.Aquasomes have wide range of applications dute to the stability provided by the oligomeric film.Aquasomes can also deliver enzymes sensitive to molecular conformation (DNAases, RNAases), pigments, dyes, vaccines, RBC and fragile substances. The active surfaces provide a base to load water in soluble drugs.In this review article, principle of self-assembly, conformational integrity, preparation of aquasomes and delivery of vaccines are discussed in a brief.

Keywords: Aquasomes, self-assembled carrier systems, ceramic cores, nanoparticles.