SOLID LIPID NANOPARTICLE: A PROMISING NANOMATERIAL IN DRUG DELIVERY

Gauri R. Kaphare*, Nikita M. Shevkar, Prathamesh M. Kulkarni, Vasim T. Pathan and Anil G. Jadhav

ABSTRACT

The virtuous or traditional drug delivery has unsuccessful in enhancement of drug bioavailability and also to decrease toxicity of drugs. In recent times, the targeted drug delivery system has gained its importance in delivering drug with low toxic levels and high bioavailability. Nanotechnology has created an revolution in the field of drug delivery. The solid lipid nanoparticles (SLNs) happens to be best drug carries. SLNs are at spearhead of speedily developing field of the nanotechnology with several applications in the drug delivery, clinical medicine, research, cosmetics, and in other various fields. It is an aqueous dispersion in which colloidal particles are formed from solid lipid that is biodegradable. SLN having size range from 1-1000nm particles use for the drug delivery system. They have been superior stability as compare with various other drug carriers as liposomes. The capability to incorporate drug into the nanoparticulate system, offers latest example in drug delivery that can be used for the drug targeting. Special attention is given to relationship between complexity of SLN dispersions and drug incorporation, SLNs preparation depends upon the nature of drug and methods involve solvent evaporation, ultra-sonication and homogenization using pressure. Bio distribution of drug is an challenge and it‟s well managed by selecting the perfect route of drug administration. Characterization of SLN includes different methods like Electronic microscopy, particle size determination. The paper gives an overview about latest research and development of SLN according to modern literature is cited.

Keywords: Characterization; Drug incorporation models; Principal of drug release; Route of administration.