EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

INFLAMMATORY MEDIATORS AS BIOMARKERS FOR ENDOMETRIOSIS

Fouad NT*, ElShennawy D, Soliman MY, Hemeda H, Khattab D, Shafik AS

ABSTRACT

The diagnosis of endometriosis, nowadays depends mainly on surgical laparoscopy, with all its known potential risks, due to the lack of a reliable diagnostic noninvasive biomarker. Serum and peritoneal TNF, IL-6, IL-8, hs-CRP, and plasma ccf nDNA levels were assessed in 120 women scheduled for diagnostic laparoscopy to investigate their roles as reliable non invasive biomarkers in the diagnosis and staging of endometriosis in Egyptian patients. The patients were divided into group I )endometriosis group = 80 patients), which is further subdivided into: group IA (stage I endometriosis =38 patients) and Group IB (stage II endometriosis = 42 patients), and Group II (non-endometriosis group= 40). Comparative statistics revealed significant difference between group I and group II regarding serum TNF-α, serum hs-CRP, serum and peritoneal IL-6 and IL-8, and plasma ccf DNA levels. Conclusion: Serum TNF-α, serum IL-6, serum IL-8, and plasma ccf DNA are possible highly sensitive reliable non-invasive biomarkers for screening of endometriosis and their routine use would indeed decrease the number of unnecessary laparoscopies. Moreover, serum IL-6 and IL-8 can be used to discriminate between various stages of endometriosis.

Keywords: Endometriosis, TNF-alpha, IL-6, IL-8, ccfDNA.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )