IS THE HOST GENETICS RESPONSIBLE FOR VARIED PRESENTATION OF COVID-19?

Ismet Nigar and Aina Niran Chowdhury*

ABSTRACT

Since COVID-19 caused by SARS CoV-2 began in Wuhan China in December, 2019, the virus is rolling on with all its might with changing modalities and infectivity across continents with more than 86 million confirmed infection and more than 1.8 million deaths. It is more worrying that the strain isolated in the UK and South Africa recently has been found to be 70% more infectious. The severe state of COVID-19 has been correlated with advanced age, diabetes, hypertension and other chronic diseases, nevertheless younger patients and even children are sometimes getting severe infection with mortality. This is sometimes unexplained. This has been widely researched and addressed with postulated genetic makeup, their blood group, immune status of the persons. The host genome, ethnicity, innate and adaptive immune response regarding SARS CoV-2 has been studied very extensively. So this review tries to look at the different insight of the genetics and its manifestations regarding severity of COVID-19, which might subsequently hold its predictability and measure to be adopted.

Keywords: COVID-19, Host genetics, ACE-2, TMPRSS2, Immune Response.