CLINICAL OUTCOME KETOFOL AND PROPOFOL IN CASE OF MINOR SURGICAL PROCEDURE IN BANGLADESH

Dr. Md. Nurul Amin*, Dr. Md. Golam Mowla, Dr. Farhana Jaya Chowdury and Dr. Md. Abdur Rahman

ABSTRACT

Background: Outpatient anesthesia for the minor day-care surgical actions needs a safe anesthesia and anesthetic agents. Objective: To evaluate effectiveness between ketofol and propofol in minor surgical procedure in Bangladesh. Methods: This experimental study is conducted at tertiary medical college and hospital, from January 2019 to March 2020, where 200 between 21-50 years old with the ASA physical status class I and II were included in the study. The study solution of Group A was prepared with 50 mg (1 ml) of Ketamine, 50 mg(5 ml) of Propofol and 4 ml of Normal Saline (NS) in a 10 ml syringe. The ratio of 1:1 was designed for ketofol group. Group A patients received 50 mg (5 ml) Ketofol (25 mg) ketamine and 25 mg propofol) and Group B received 50 mg(5 ml) of propofol. Result: During the study, in group-A, duration of surgery was 16.21 ± 9.3 min whereas in group-B it was 18.25 ± 9.5. According to intraoperative complication where in group-A, 14% had decreased level of SPO2<90% where as in group-B it was 22% followed by 11% had apnea in group-A whereas in group B it was 9%. Also, in group A 3% had slow respiration, in group B it was 7%. Mean induction time for group-A was 30.20±4.17where as in group-B it was 42.35±5.13. In postoperative complications where in group. Conclusion: In mild surgical operations, mixing ketamin (ketofol) with propofol alone has some benefits relative to anesthesia. Because of the complementary action of reducing the dosage of both medications, the mixture has fewer antagonistic effects than each drug itself. For better outcomes, further analysis is needed.

Keywords: Ketofol, propofol, surgical procedure.