IMPACT ON CALCIUM AND MAGNESIUM LEVELS DURING AUTOMATED PLATELETPHERESIS IN NORMAL DONORS

Dr. Atiar Rahman*, Dr. Farah Anjum Sonia, Dr. Sheikh Saiful Islam Shaheen, Dr. Kashfia Islam, Dr. Iffat Ara Akbar, Dr. Zia Uddin Ahmed and Dr. Shahanaj Parveen

ABSTRACT

Background: Utilization of apheretic platelet is increasing day by day due to rapid up gradation of technology in Transfusion Medicine. In Bangladesh requirement of apheretic platelet is increasing due to adoption of advance treatment. Physician are using apheretic platelet due to some advantages over random donor platelet. Though it is a blood donation procedure there is little concern about donor adverse reaction and biochemical changes due to citrate utilization. Objective: The aim of our study was to evaluate biochemical changes especially in Calcium and Magnesium during collection of platelet by apheretic procedure. Our goal was to also evaluate effect of citrate in these two elements. Method: It was a observational study which will be carried out at Transfusion Medicine department, Bangabandhu Sheikh Mujib Medical University, Dhaka from July 2019 to June 2020. Healthy donors was underwent intermittent flow cell separator (MCS 3p, Hemonetics, Braintree, MA, USA). Serum levels of total calcium (tCa ) and Mg (tMg) will be measured before, during and after the procedures. Results: Our study showed that there was significant change in Calcium level (P <0.001). Serum calcium level fell from 9.24±0.72 mg/dl to 8.43±1.38. But after donation there was no significant change in Magnesium level (P=0.939). Conclusion: Our study showed almost 9% reduction of serum calcium level after platelet donation. But there was no significant change in serum Magnesium level which is good sign for aphaeretic platelet donation.

Keywords: Apheretic platelet, biochemical, citrate, anemia, thrombocytopenia.