NONSYNDROMIC FAMILIAL HYPODONTIA: GENETIC STUDY

Cristina-Crenguta Albu*, Marina Imre, Ana Maria Cristina Tancu and Stefan-Dimitrie Albu

ABSTRACT

Hypodontia is a dental number anomaly characterized by the partial absence of teeth. We are presenting the family genetic study of hereditary, nonsydromic hypodontia, illustrating the heterogeneity of phenotypic expression of hypodontia, amongst two successive generations. The genetic study was performed by the Genetics Department of A.S. Medical Center, in Bucharest, Romania. The clinical and paraclinical examination of the patients was completed by the photographic examination, the family investigation, the genealogical tree and the analysis of the studied family’s genealogical tree, after acquiring the informed consent of the patients. The genetic study allows for the assessment of the dental number anomalies, from the point of view of the genetic factor involvement in their etiology, it facilitates determining the disorder’s recurrence risk within the studied family, it allows for the early diagnosis of the disorder, preventing complications.

Keywords: Nonsyndromic, hypodontia, genetic study, autosomal dominant, family tree.