EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DETECTION OF HBsAg IN RENAL TISSUE OF PATIENTS WITH GLOMERULONEPHRITIS

Dr. G. M. Hafizur Rahman*, Professor (Dr.) Muhammad Rafiqul Alam, Dr. Hossain Muhammad Mustafijur Rahman, Dr. Al Asma Ul Taslima, Dr. Tanvir Rahman, Dr. Faruque Ahmed, Dr. Nahid Afrin, Dr. Md Dilder Hossain Badal and Dr. Golam Mahbub Sikder

ABSTRACT

Introduction: Hepatitis B virus infection is a severe public health problem worldwide and it causes not only hepatic diseases but also extra hepatic manifestations particularly HBV-associated Glomerulonephritis (GN). HBsAg has been observed in the glomeruli of some patients with glomerulonephritis. HBV related glomerulonephritis may be found in HBV seropositive as well as seronegative patients. HBV may present in the renal tissue of such patients. In most cases detection of HBsAg in the renal tissue by renal biopsy and immunohistochemistry can establish the etiology. Objective: To estimate the frequency of HBsAg deposition in renal tissue of patients with glomerulonephritis. Method: This cross sectional study was done in the Department of Nephrology, BSMMU, during the period of July 2015 to June 2016. A total number of 53 cases who fulfilled the inclusion and exclusion criteria were selected as sample. Samples were selected by purposive sampling technique. Results: HBsAg antigen in renal tissue was found in 2 patients among 7 patients who were seropositive for both HBsAg and Anti HBc(total), 2 patients among 8 patients who were HBsAg seronegative but Anti HBc (total) seropositive , 2 patients among 38 patients who were seronegative for both HBsAg and Anti HBc(total). There were no patients in this study who was HBsAg seropositive but Anti HBc (total) seronegative. Total 11.3% (6 patients) of renal biopsy specimens were found to have HBsAg deposits which included 3 cases of Membranoproliferative GN and one of each of Membranous nephropathy, Mesangial proliferative GN and IgA nephropathy. Conclusion: The high rate of HBsAg deposits found in renal tissue indicates that detection of HBsAg deposition should be done for all histological varieties of GN. So that antiviral therapy can be used to stop progression of HBV associated nephropathy.

Keywords: HBsAg, Anti HBc (total), Renal Biopsy, Glomerulonephritis.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: MARCH ISSUE PUBLISHED

    MARCH Issue has been successfully launched on 1 March 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )