EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PRESENCE OF ANTI-CARDIOLIPIN ANTIBODY AND ITS ASSOCIATION WITH NEUROPSYCHIATRIC MANIFESTATIONS IN PAEDIATRIC SLE PATIENTS

Ali Hasan Farid, *Mohammad Imnul Islam, Mohammed Mahbubul Islam, Manik Kumar Talukder, Gopen kumar Kundu, Shahana Akhter Rahman

ABSTRACT

Background: Neuropsychiatric (NP) manifestation is one of the most critical and severe presentations in paediatric SLE (pSLE) patients. It comprises a wide range of neurological symptoms affecting the central, peripheral, autonomic nervous systems and psychiatric symptoms. One of the most intriguing issue is the association of neuropsychiatric manifestation with anti-cardiolipin (aCL) antibody. Objectives: To identify the anti-cardiolipin antibody frequency, its association with NP manifestations and MRI of brain findings in pSLE patients. Methods: This was a cross-sectional study conducted in the Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), from June 2017 to May 2018. Newly diagnosed 50 pSLE patients who fulfilled the ACR criteria were enrolled in this study. Clinical information and laboratory investigations, including aCL antibody were measured and recorded in a pre-designed questionnaire. MRI of the brain was also done in all NP-SLE cases. Result: Neuropsychiatric manifestations were found in 40% of pSLE patients. Headache, convulsion, and mood disorder were common NP manifestations. This study found that aCL antibody positivity was present in 52% of pSLE patients. Abnormal MRI findings were observed in 55% of NP-SLE patients and cerebral atrophy was the commonest abnormality. A significant association with aCL antibody and MRI findings was found. Conclusion: Anti-cardiolipin antibody was present in 52% of pSLE patients. Associations between NP manifestations with MRI findings was found significant.

Keywords: Anti-cardiolipin (aCL) antibody, Neuropsychiatric manifestation, paediatric SLE.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: MARCH ISSUE PUBLISHED

    MARCH Issue has been successfully launched on 1 March 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )