EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

USES OF DEXMEDETOMIDINE AND FENTANYL AS ADJUVANTS IN EPIDURAL BLOCK WITH COMBINED ANAESTHETIC TECHNIQUE FOR GASTRECTOMY SURGERY

Dr. Sabina Yeasmeen*, Dr. Md. Sanaul Hoque Masud, Dr. Montosh Kumar Mondal, Dr. A. K. M. Faizul Hoque and Dr. Debabrata Banik

ABSTRACT

Background: Opioids as epidural adjunct to local anaesthetics have been in use so long and the synergism between epidural local anaesthetic agents and opioids are well established. Dexmedetomidine (α-2 agonist) is being increasingly used for similar purpose but evidence for the combination of local anaesthetic agents with dexmedetomidine in epidural analgesia is limited. Gastic cancer is increasing day by day in our country and removal of tumor by gastrectomy surgery is choice of treatment. The present study was conducted to compare the analgesic, hemodynamic, sedative effects of epidurally administered dexmedetomidine and fentanyl when combined with bupivacaine in a patient undergoing gastrectomy surgery along with general anaesthesia. Objective: Compare the effectiveness of epidural dexmedetomidine and fentanyl as an adjuvant to bupivacaine in gastrectomy surgery under general anaesthesia. Materials and Methods: This randomized controlled trial study was carried out in the Department of Anaesthesia, Analgesia and Intensive Care Medicine, BSMMU, Dhaka. The study was been conducted May 2019 to April 2020 after obtaining approval from the institutional Review Board and informed written consent from the patients. About 40 patients aged between 40 and 70 years, posted for gastrectomy surgery were included in this study. The patients were randomly allocated into two equal groups. Group A received general anaesthesia along with epidural fentanyl and bupivacaine. Group B received general anaesthesia along with epidural dexmedetomidine and bupivacaine. Results: Age, height, and weight were almost identical between two groups. Duration of surgery and anaesthesia were almost similar between two groups. Systolic blood pressures, diastolic blood pressure, MAP were almost similar between two groups and were statically not significant (p>0.05). Mean heart rate of group B was significantly lower (p<0.05) than that of group A. Post operative visual analog scale was reduced significantly (p<0.05) in group B than group A. The time of first analgesic requirement was significantly higher (p<0.05) in group B. The mean sedation score was also significantly higher (p < 0.05) in group B than group A. Conclusions: Dexmedetomidine seems to be a better alternative to fentanyl as an epidural adjuvant to local anaesthetics as it decreases pain intensity during post operative period, delayed time of first analgesic supplementation, provides better sedation level without harmful derangement on hasemodynamics.

Keywords: Dexmedetomidine, gastrectomy surgery, haemodynamic, anaesthesia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )