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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Avinash S. Gudigennavar*, Jayadev N. Hiremath, Prabhu K. Halakatti, Shivashankar V. Shingashetti, Pratiksha C. Chandragirivar and Dr. Anita R. Desai


The aim of this work was to develop a fast dissolving tablets of Valsartan drug by direct compression method using different natural and synthetic super disintegrants. The fast dissolving tablets of Valsartan were prepared by direct compression method. The physicochemical parameters like pre-compression and post-compression evaluation were performed as per pharmacopoeia standards and compatibility study was done by FTIR method. The release data were subjected to different models in order to evaluate their kinetics and release mechanism. Direct compression method using different natural and synthetic super disintegrants. The compatibility study of the drug with various polymers, IR spectra of drug and polymers were carried out. The FTIR spectral analysis showed that there was no drug interaction with formulations additives of the tablet as there is no variation and shift in bands, it can be justified there is no interaction between drug and polymer. The Solid dispersion with 1:3 ratio shows better aqueous solubility which explains better dissolution rate of the drug. Various batches of FDTs were prepared using selected ratio of SD. Pre compression parameters showed good flow properties. Post compression parameters like thickness, hardness, weight-variation, friability, wetting-time, water absorption ratio, disintegration time, drug content, in-vitro drug release study shown good results. Formulation F3 and F5 showed good results throught the study. Short term stability studies on the formulations F3 and F5 indicated that there are no significant change in the hardness, friability, disintegration time, drug content and in-vitro drug release study. The release kinetics data implies that the formulation was First order and Peppas models. From the results, it was concluded that the FDTs of valsartan containing seeds of Plantago ovata mucilage (F3) and leaves of Hibiscus rosa sinensis (F5) are showed disintegration time and in-vitro drug release study faster than the synthetic super disintegrants like croscarmellose sodium and crospovidone.

Keywords: Fast dissolving drug delivery systems (FDDS); Solid dispersion (SD): Valsartan; Hibiscus rosa sinensis (HRS); Plantago ovata mucilage (POM).

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )