EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CARBENDAZIM INDUCED OXIDATIVE STRESS AND REDUCED BRAIN ACETYLCHOLINESTERASE ACTIVITY IN ZEBRAFISH

Rakesh Kullayi Swamy, Bestha Lakshmi and *Gundala H. Philip

ABSTRACT

Carbendazim (CBZ) is a widely used broad spectrum fungicide applied during the pre- and post- harvest times of food crops. It is mainly applied to control the Ascomycetes, Fungi imperfecti and Basidiomycetes fungal diseases. WHO categorized CBZ under hazardous chemicals and classified as a human carcinogen. It exhibits fungicidal activity by binding to the spindle microtubules causing the nuclear division blockade. As it is considered as an effective fungicide it has been widely applied and humans are mostly exposed to it. Besides its antifungal activity CBZ has toxic effects on humans who use it. In the current experimental study prolonged exposure (42 days) effects of CBZ on liver, gill and brain tissues of zebrafish has been observed. The toxic effect of CBZ on first line defense mechanisms like antioxidant enzymes i.e., catalase (CAT), Superoxide Dismutase (SOD), Glutathione Reductase (GR), Glutathione Peroxidase (GPx), Lipid Peroxidation (LPO) and brain acetylcholinesterase (AChE) has been studied at intervals of 1, 21 and 42 days. The results show that the activity of antioxidant enzymes was increasing with the exposure time but it was always less than the control groups. Lipid peroxidation has showing a significant increase and AChE was decreased throughout the exposure time in the treated groups.

Keywords: Carbendazim, fungicide, zebrafish, Oxidative, Acetylcholinesteras.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )