EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHYTOCHEMICAL INVESTIGATION OF THE FRUITS OF COCCINIA INDICA AND LEAVES OF TRICHODESMA INDICUM

Showkat Rassol Mir, Mohammed Ali*, Vidhu Aeri and Ujjwal Kaushik

ABSTRACT

Coccinia indica Wight et Arn. (family Cucurbitaceae) is a dioecious, perennial climber with ovoid-oblong, fleshy fruits. Its fruits are edible, used to treat abscesses, asthma, bronchitis, diabetes, fever, hypertension, jaundice, leprosy and tongue sores. Trichodesma indicum (L.) Lehm. (family Boraginaceae) is an erect, spreading, branched, annual plant. Its leaves are utilized as a diuretic and to relieve anorexia, arthritis, bleeding, cuts, dysentery, skin diseases, snake bites, stomach disorders, toxicity, urinary diseases and wounds. Our study was planned to isolate chemical constituents from the fruits of C. indica and leaves of T. indicum and to characterize their structures. Phytochemical investigation of a methanolic extract of the fruits of C. grandis afforded two new fatty acid glucosides identified as (Z)-docos-13-enoyl O-α-D-glucopyranoside (erucicyl-O-α-D-glucoside, 1) and n-docosanoyl O-α-D-glucopyranoside (behenyl-O-α-D-glucoside, 2) and two steroidal glucosides, viz., β-sitosterol 3-O-α-D-glucopyranoside (3) and β-sitosterol 3-O-α-D-glucopyranosyl-((6'→1'')-O-α-D-glucopyranosyl-(6''→1''')- O-α-D-glucopyranoside (β-sitosterol α-D-triglucoside, 4). The leaf methanolic extract of T. indicum furnished three fatty acid esters characterized as n-pentadecanyl octadec-9-enoate (n-pentadecanyl oleate, 5), 1-nonacosanolyl (9Z)-octadecenoate (n-nonacosanyl oleate, 7) and n-triacontanyl octadec-9-enoate (n-triacontanyl oleate, 8) and a higher aliphatic carboxylic acid, viz., n-dotriacont- 5(Z),18(Z)-dienoic acid (6). The structures of all these compounds have been established on the basis of spectral data analyses and chemical reactions.

Keywords: Coccinia indica fruits, Trichodesma indicum leaves, phytoconstituents, isolation, characterization.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )