ASSESSMENT OF QUALITY OF LIFE, COMPLIANCE AND ADVERSE DRUG REACTIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
Dr. Basavanna P. L.*, Joicy James, Kadeejath Sayitha, Mohammed Musthafa K. and Mohammad Rowghani
Background: Chronic obstructive pulmonary disease is a common condition and is characterised by limitation in airflow, which is not fully reversible. It is one of the most common causes of disease burden both globally and in India. Multiple drugs used in the treatment of COPD may increase the risk of ADR in these patients. So it is very important to monitor ADR in these patients to rationalise drug therapy. Since COPD is a chronic condition and not fully curable, it is necessary to assess the medication adherence and quality of life. Objectives: The main objective of the study was to assess the quality of life, compliance and adverse drug reactions in chronic obstructive pulmonary disease patients. Materials and Methods: Study was carried at pulmonology department, in PKTB hospital, Mysore, Karnataka, from November 2018 to April 2019. A total of 252 patients were enrolled in the study as per the inclusion and exclusion criteria. Patients demographics data were collected using data collection form and quality of life were assessed by using St. George’s questionnaire. The adverse drug reactions were analysed by using Naranjo causality assessment scale and Hartwig’s scale and medication adherence were analysed by Morisky Green Levine 4-Item (MGL-4) Medication Adherence Scale. The domains associated with each objective were identified and correlated with multiple factors. Results: Out of 252 candidates, males show dominance over females .75 were presented with ADRs (29.8%). Stomach upset was the most commonly reported ADR .53.33% of ADRs were mild and 46.66% were moderate. 63% of ADRs were probable and 37% were in the possible category. In our study, medium adherence (52%) has superiority over low (35.3%) and high adherence (12.7%). Among the study population, QoL is highly impaired in terms of all the 3 domain such as symptom, activity and impact component. The activity component is most affected and symptom component is least affected. Conclusion: The study was conducted to enhance the overall quality of life among the COPD patients. It can be improved by providing education and awareness about the disease and importance of medication adherence among the study population.
Keywords: Adverse drug reaction (ADR), Chronic Obstructive Pulmonary Disease (COPD), MGL-4 medication adherence scale (Morisky Green Levine 4-Item), Quality of life (QoL).
[Full Text Article]