EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

ASSESSMENT OF QUALITY OF LIFE, COMPLIANCE AND ADVERSE DRUG REACTIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

Dr. Basavanna P. L.*, Joicy James, Kadeejath Sayitha, Mohammed Musthafa K. and Mohammad Rowghani

ABSTRACT

Background: Chronic obstructive pulmonary disease is a common condition and is characterised by limitation in airflow, which is not fully reversible. It is one of the most common causes of disease burden both globally and in India. Multiple drugs used in the treatment of COPD may increase the risk of ADR in these patients. So it is very important to monitor ADR in these patients to rationalise drug therapy. Since COPD is a chronic condition and not fully curable, it is necessary to assess the medication adherence and quality of life. Objectives: The main objective of the study was to assess the quality of life, compliance and adverse drug reactions in chronic obstructive pulmonary disease patients. Materials and Methods: Study was carried at pulmonology department, in PKTB hospital, Mysore, Karnataka, from November 2018 to April 2019. A total of 252 patients were enrolled in the study as per the inclusion and exclusion criteria. Patients demographics data were collected using data collection form and quality of life were assessed by using St. George’s questionnaire. The adverse drug reactions were analysed by using Naranjo causality assessment scale and Hartwig’s scale and medication adherence were analysed by Morisky Green Levine 4-Item (MGL-4) Medication Adherence Scale. The domains associated with each objective were identified and correlated with multiple factors. Results: Out of 252 candidates, males show dominance over females .75 were presented with ADRs (29.8%). Stomach upset was the most commonly reported ADR .53.33% of ADRs were mild and 46.66% were moderate. 63% of ADRs were probable and 37% were in the possible category. In our study, medium adherence (52%) has superiority over low (35.3%) and high adherence (12.7%). Among the study population, QoL is highly impaired in terms of all the 3 domain such as symptom, activity and impact component. The activity component is most affected and symptom component is least affected. Conclusion: The study was conducted to enhance the overall quality of life among the COPD patients. It can be improved by providing education and awareness about the disease and importance of medication adherence among the study population.

Keywords: Adverse drug reaction (ADR), Chronic Obstructive Pulmonary Disease (COPD), MGL-4 medication adherence scale (Morisky Green Levine 4-Item), Quality of life (QoL).


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )