EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NOVEL DRUGS AND THEIR COMBINATIONS USED FOR TREATING AIDS

Mehnaz Showkat, Humaira Bilal, Bilquees and Nahida Tabassum*

ABSTRACT

Over past 35 years HIV/AIDS has emerged as a major global health problem across the globe. Although the Highly Active Antiretroviral Therapy (HAART) has significantly contributed to the suppression of viral load and has greatly prolonged the patient survival rate, issues such as complexity of the regimen, drug interactions, adverse effects, cross resistance between the drugs, still pose a hurdle to successful treatment. There is a persistent need of newer antiretroviral drugs (ARVs) with increased potency, improved pharmacokinetic profiles and improved activity against resistant HIV strains. Proper understanding of HIV life cycle and interaction of the virus with host cell factors has led to the development of newer and effective ARVs like, Ibalizumab, Fostemsavir, Doravirine etc. These drugs offer a number of advantages over traditional drugs and present a new choice for patients with drug resistant disease. Fixed Dose Combinations (FDC’s) of currently available drugs have proven beneficial by reducing risk of emergence of drug resistant strains, less risk of medication errors, better patient compliance, reduced cost of treatment and simplified drug supply management. Besides, drugs belonging to different classes are currently in different stages of clinical trials, thus broadening the future scope of treatment.

Keywords: HIV/AIDS, HAART, ARVs, Fostemsavir, Elsulfavirine, FDC’s.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • EJPMR JANUARY ISSUE PUBLISHED

    JANUARY Issue has been successfully launched on 1 January 2021.

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2020 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR NOVEMBER ISSUE PUBLISHED

    NOVEMBER 2020 Issue has been successfully launched on 1 November 2020.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )