EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A HIGH PROFILE REVIEW ON NEW ORAL CLOTTING FACTOR XA INHIBITOR: BETRIXABAN

Nikunj Patadiya* and Rajesh Dumpala

ABSTRACT

Venous thromboembolism is commonly defined as a situation in which blood clot forms in blood vessels. It has two types Deep vein thrombosis (clot became in leg, groin or arm) and pulmonary embolism (clot became in circulation, lodging in lungs). For the treatments of this condition number of medicines are used like unfractionated heparins, low molecular weight heparins(LMWH), warfarin, and vitamin K antagonists.[1] They all agents have their own side effects and efficacy. Long term treatment causes pain, redness, irritation, bluish colored skin etc. For reduce side effects and improve efficacy the novel anticoagulants are required. New agents like enoxaparin, apixaban and rivaroxaban is use for the treatments of Venous thromboembolism but clinical trails shows higher risks of major bleeding.[1] Betrixaben is approved by FDA in class of clotting factor Xa inhibitor. Betrixaban became first anticoagulant(by inhibit factor Xa) approved in the United States (US) for prophylaxis of venous thromboembolism extending away from hospitalization.[2,3] Its have unique pharmacokinetic properties, long half-life, low metabolism rate by cytochrome p450 and not metabolized by CYP3A4 system and less renal excretion.[1] In this article, we review on its pharmacological effect, clinical trail study results, comparition with other anticoagulants, its side effects and use against Venous Thromboembolism and other pathological conditions.

Keywords: Betrixaban, venous thromboembolism, pharmacokinetics, clinical trails, adverse effects.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )