EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF LINEZOLID FILM COATED TABLETS

Surbhi Sirswal* and Aman Mittal

ABSTRACT

The present investigation is undertaken with an aim to formulate and evaluate Film coated tablet of linezolid. The drug powders were subjected for preformulation studies. The Preformulation characteristics are within the Pharmacopoeial specifications. The drugs and excipients compatibility were carried out by FT-IR studies. The spectra showed that there was no interaction between them. The dissolution profile were carried out in Dissolution apparatus and then in UV spectrophotometer. For Linezolid-600 mg tablets, the main purpose of this study is to improve the hardness and dissolution profile of the core tablet and to minimize the defects occurs during coating of tablet. Optimization was done and it was found that dissolution release profile and hardness were found to be best and after coating, the tablet was found without any coating defect by non-aqueous coating i.e. IPA. Film coating of TiO2 and IPA coating of 2 %w/w was done on Linezolid tablets as to avoid spores which occurs during the aqueous coating. Five formulations were prepared by the name of SAD01-SAD-05. For coating, two different types of coating material were used (aqueous coating and non-aqueous coating). The granules were evaluated for angle of repose, bulk density, compressibility index and drug content etc. The tablets were also subjected for thickness, hardness, friability and in vitro release studies. Evaluation parameters like weight variation, hardness, thickness, friability and disintegration test were performed. Results found that release profile of batch no. SAD-05 shows better hardness and dissolution profile of core tablet and good coating appearance after non-aqueous coating. This formulation is taken as an ideal or optimized formulation.

Keywords: Linezolid; Preformulation; Film Coating; Hardness; Dissolution study etc.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )