EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE EFFECT OF DIABETES LEVEL OF CONTORL ON COVID-19 SEVERITY AND MORTALITY: A RETROSPECTIVE COHORT STUDY

Dr. Nada Bassam Rabie*, Dr. Muneera Abdulmalik Alshareef, Dr. Samia Abdullah Bokhari, Dr. Abdullah M. Mallisho, Dr. Turki Abdulaziz Alharthi, Dr. Ghada Asim Rayes, Dr. Waleed Omar Bawazeer, Dr. Rehab Mahmoud Elboraie, Dr. Ameera Husseian Alzahrani, Dr. Hamdy Abdelwareth Alkady, Dr. Mohamed Sayed Galal and Hanin Abdulhameed Shalaby

ABSTRACT

Introduction: Since the beginning of COVID-19 pandemic, diabetes has been recognized to have important impact on the overall disease outcomes, including mortality. Exactly how this effect can vary according to the level of diabetes control is still unclear. Method: We conducted a retrospective cohort study to examine the association between disease outcome in terms of COVID-19 severity and mortality and the level of diabetes control. We collected data on baseline characteristics, HbA1C level, the total basal and bolus insulin and any previous documented complication such as diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemia (HHS). We compared the diabetes control before and after COVID infection. Results: 154 patients were included in our study. Mean age was 59.85 and 56% were males. Even in patients with Good/Fair diabetes control (HbA1C <8%), more than half presented with moderate CVOID-19 severity. Fasting blood sugar was elevated in 66%. While none developed HHS, 2% developed DKA. The mean length of hospital stay was 8 days. Even though mortality rate didn’t vary across various levels of diabetes control, the need of insulin infusion was more in non-survivors (33% vs 4% in survivors, p-value 0.04). Conclusion: Our study clearly demonstrates that diabetes among hospitalized patients with COVID-19 puts them at higher risk of morbidity and mortality. This was especially associated with uncontrolled fasting hyperglycemia (>7mmol/L). Effective measures such as implementation of hyperglycemia algorithm for hospitalized patients and follow up plan should be implemented.

Keywords: COVID-19, diabetes mellitus control, SARS-CoV-2, COVID-19 severity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )